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Female abnormalities are due to variations in the number of X chromosomes.

Men who are mosaic (XY/XXY) generally have the least problems.

Like Down syndrome and other autosomal problems, sex chromosome gross abnormalities can be diagnosed before birth by amniocentesis and chorionic villi sampling. Normal males inherit an X and a Y chromosome while females have two X's.

A single Y chromosome is sufficient to produce maleness while its absence is necessary for femaleness.

The feminizing effects of this hormonal imbalance can be significantly diminished if Klinefelter syndrome boys are regularly given testosterone from the age of puberty on.

Like (described above), many Klinefelter syndrome men are an inch or so above average height. They usually have learning difficulties as children, especially with language and short-term memory.

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